Biomaterial-driven kidney organoid maturation

Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect organoid generation. We summarize adhesive cues materials, allow transduction the mechanical forces cell, how these signals directly Hippo-Canonical Wnt signaling morphogenic events. In addition, chemical strategies are discussed spatiotemporal presentation biochemical agents cell in material-dependent approach.